Li Lab

Work With Us

Join the Lab

The lab is newly established and actively recruiting. We are looking for people who like building methods and care about the biology those methods reveal — based at Massachusetts General Hospital and the Broad Institute, with close ties to experimental collaborators.

Our Lab Culture

Collaborative, not competitive
Open science & reproducibility
Mentorship at every career stage
Work-life integration
Inclusive & welcoming environment
Interdisciplinary thinking

Open Positions

Postdoctoral Fellow — Microbial Metabolism & Multi-Omics

We are recruiting a postdoctoral fellow to work on longitudinal microbiome and metabolome data from the Framingham Heart Study, connecting microbial enzymes and metabolites to host cardiometabolic trajectories. The project suits someone who enjoys building methods and following them through to biological interpretation, with close access to experimental collaborators at MGH and the Broad.

  • PhD in computational biology, bioinformatics, computer science, statistics, or a related field
  • Strong programming in Python and/or R, and comfort on HPC or cloud infrastructure
  • Experience with metagenomics, metabolomics, or mass spectrometry data analysis
  • A track record of first-author work, and interest in mechanistic microbiology

Postdoctoral Fellow — Sepsis Multi-Omics

Supported by a Broad CISID New Investigator Award, this project asks whether the serum metabolome encodes sepsis sub-phenotypes that explain the field's persistent heterogeneity in treatment response. The work involves characterizing uncharacterized ("dark matter") metabolites and deconvoluting untargeted metabolomics into cell-type-specific pathways using single-cell transcriptional references.

  • PhD in computational biology, machine learning, statistics, or a related quantitative field
  • Experience with untargeted metabolomics, single-cell transcriptomics, or clinical cohort data
  • Interest in interpretable models and clinical translation
  • Ability to work closely with clinicians and experimentalists

Graduate & Rotation Students

Students in Harvard and MIT graduate programs are welcome to rotate with us. Projects can be fully computational or paired with wet-lab collaborators, depending on your interests. Please get in touch to discuss what is currently available.

  • Enrolled in a Harvard, HMS, or MIT graduate program
  • Background in computational biology, quantitative science, or microbiology
  • Willingness to learn programming if you have not done much before

How to Apply

Please send the following by email to Chenhao, with the subject line “[Position] Application – [Your Name]”:

  • 1.CV / Resume
  • 2.Brief statement of research interests and why you want to join our lab (1–2 pages)
  • 3.Contact information for 2–3 references
  • 4.Representative publications or writing samples (if applicable)

Have questions?

We're happy to discuss opportunities informally before a formal application.

Get in Touch